Containing Hypertrophy With a PICOT Fence
نویسندگان
چکیده
منابع مشابه
Containing hypertrophy with a PICOT fence.
Why Is a Big Heart a Bad Thing? From the perspective of cardiac mechanics, it seems surprising that cardiac hypertrophy is a killer. The physics of reactive hypertrophy date to the 19th century1 and predict that hypertrophy will compensate for increased hemodynamic loading through normalization of ventricular wall stress, the phylogenetically conserved set point for cardiac load.2 The Laplace r...
متن کاملPICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling.
PICOT (protein kinase C-interacting cousin of thioredoxin) was previously shown to inhibit pressure overload-induced cardiac hypertrophy, concomitant with an increase in ventricular function and cardiomyocyte contractility. The combined analyses of glutathione S-transferase pull-down experiments and mass spectrometry enabled us to determine that PICOT directly interacts with muscle LIM protein ...
متن کاملPICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility.
Multiple signaling pathways involving protein kinase C (PKC) have been implicated in the development of cardiac hypertrophy. We observed that a putative PKC inhibitor, PICOT (PKC-Interacting Cousin Of Thioredoxin) was upregulated in response to hypertrophic stimuli both in vitro and in vivo. This suggested that PICOT may act as an endogenous negative feedback regulator of cardiac hypertrophy th...
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BACKGROUND Many articles written about the PICOT (Population, Intervention, Comparison, Outcome, Time) method for developing research questions focus on searching the existing evidence base to review the impact of interventions. The PICOT method evolved to craft questions that yield operative search terms. Currently, the PICOT method falls short in its utility for health care and doctoral educa...
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A fence, represented by a unit interval is to be patrolled collectively by n robots. At any moment a robot may move in one of the two possible states: walking or patrolling. Each state is associated with a maximal moving speed which cannot be exceeded. A robot may have a unique pair of speeds, but its patrolling speed is always smaller than its walking speed. Each robot is allowed to patrol whi...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2006
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000236795.57759.45